10 Essential Ingredients

10 Science-Backed Vitamins and Supplements that Clinical trials have shown will help you relieve the symptoms and, over time, may even help support reversing them

If you suffer from nerve pain, you really need to be taking these 10 vitamins and supplements… So, let’s see what they are:

Alpha Lipoic Acid

An essential fatty acid known as (ALA) is a compound produced in the body which is present in all of your cells.

ALA plays a vital role in the performance of many of your body’s functions especially with regard to the metabolism of glucose; it is both a powerful antioxidant and helps produce energy from blood sugar. Alpha lipoic acid is already used to treat diabetic neuropathy in Germany and is an approved treatment in that country.

According to research, it can help those suffering from diabetic neuropathy by positively influencing the metabolism of glucose. 

Research has also demonstrated that ALA improves the flow of blood to the nerves allowing them to use energy efficiently. 

The results of clinical trials have been promising. One particular trial demonstrated that alpha lipoic acid taken at doses of 600 mg daily for a 3-week period led to very significant improvements in neuropathic symptoms. Both the sensations of burning and pain were significantly reduced. 

Another trial found that a dose of just 600 mg a day improved symptom and slowed down the progression of neuropathy. The results seem very promising especially with regards to diabetic neuropathy. However, and this is very important… the trials and tests were all done with 600 mg of ALA… 

So, if you’re taking a supplement or thinking of taking one if it does not have 600 mg of ALA, move on and find something that does straight away.


The B- Vitamins are a group of vitamins that play many vital roles in the body including nerve function and generating cellular energy.

Thiamine and Benfotiamine

According to research, a thiamine deficiency can directly lead to neuropathy and there is some evidence that thiamine supplements can help treat the condition, especially diabetic neuropathy.

Benfotiamine is derivative of thiamine which is fat-soluble and more easily absorbed into the digestive system.

According to the research, Benfotiamine modulates the pathways that cause neuropathy. It regulates cellular damage caused by high levels of glucose and prevents vascular problems that also contribute to neuropathy.

Several trials have demonstrated that Benfotiamine taken at doses between 300 and 600 mg a day can significantly relieve the symptoms of diabetic neuropathy.

Again, anything less than 300 mg a day is a waste of money.

Vitamin B12 and Vitamin B6

Vitamin B12 is absolutely crucial to a well-functioning nerve system and a deficiency can lead directly to peripheral neuropathy.

Several studies on humans have offered promising results so far, studies have demonstrated that Vitamin B12 can extenuate nerve damage caused by neuropathy by activating a chemical signal, which helps nerves to regenerate.

Clinical trials have also demonstrated how significant Vitamins B12 and B6 are in the treatment of neuropathic symptoms.

Combinations of Vitamin B12 and B6 have been found to improve symptoms and maintain the health of nerves in the extremities. 

Another study found that a combination of the same B-Vitamins reduced periods of hospitalization and medical costs in those with diabetic neuropathy.

What’s Important here is to look for a combination of B6 and B12 at 1500 mg a day or more.

Vitamin C

This vitamin is especially significant to diabetic neuropathy because research shows that most diabetics have a lack of Vitamin C as a result of their illness rather than diet.

Those suffering from diabetic neuropathy have an elevated level of vitamin c which the body has already used known as reduced Vitamin C. 

This implies that neuropathy places an extra strain on the body’s Vitamin C stores. As a result, it is important for diabetics to get sufficient levels of this vitamin through supplementation or diet.

This is especially important to diabetics… So, look and see if your supplement has Vitamin C.

Vitamin E

Lower levels of Vitamin E can also be seen in people suffering from diabetic neuropathy.

Research has shown that supplementing with Vitamin E alone can improve peripheral neuropathy symptoms and improve nerve function and health in those with type 2 diabetes. 

Again, look and see if your supplement has Vitamin E.

Vitamin D

A deficiency in Vitamin D may be a risk factor in peripheral diabetic neuropathy. 

A deficiency is typically present in those with type 1 and 2 diabetes and is even more common in those suffering neuropathy symptoms.

One study published in 2008 was carried out on 51 patients and found that supplementing with Vitamin D reduced pain levels by up to 50%. 

Acetyl L-Carnitine

This is an amino acid which is often used to treat a range of illnesses including Alzheimer’s disease, diabetic neuropathy and other forms of neuropathy.

Because carnitine is often lacking in those with diabetic neuropathy, there has been some research to evaluate the role of supplementation.

According to research, supplementing with carnitine might help increase insulin resistance, allow the cells to utilize glucose effectively and boost nerve regeneration. 

Several studies into the effects of carnitine have discovered that it helps reduce pain, improves the sensation of vibration in the limbs and helps nerves to regenerate. 

Note: People taking blood thinning medications like warfarin should not use l-carnitine. The combination increases the effects of warfarin and can increase the risks of bleeding.


This is an amino acid which is often used to treat a range of illnesses including Alzheimer’s disease, diabetic neuropathy and other forms of neuropathy.

Curcumin is a yellow colored pigment extracted from a plant called Curcuma longa. There is a great deal of excitement that curcumin could be used as a supplement for those suffering from neuropathy.

It is an excellent anti-inflammatory and according to research might be able to reduce pain signals caused by damaged nerves as well as prevent oxidative damage of the nerves.


Research suggests that the majority of us in the West are deficient in magnesium. It performs many vital functions including clotting the blood and allowing proper muscle and nerve function.

According to research, diabetic neuropathy symptoms are exacerbated by magnesium deficiencies and it is recommended that supplements are used because we do not get enough from our diets.

So, there you have it, 10 Science-Backed Vitamins and Supplements for Neuropathy with clinical proof to help you relieve and even help promote the reversal of your nerve damage, what’s important for you to remember is that the dosage and the combination of all these ingredients will affect the results you get.

Simply having ALA is not enough, it must be 600 mg if you hope to get the same support achieved in the clinical trials.

One other point to remember, natural supplements take time to work, nerve repair is a slow process, sometimes 2 or 3 months to see the benefits.

And finally, after reviewing and comparing the bestselling supplements available on Amazon and doing extensive research into the company, ingredients, reputation, and effectiveness, we found that only one product has all 10 Science-Backed Vitamins and Supplements vital for neuropathy pain relief Support in the correct dosage including ALA at 600 mg. Plus, it has 8 other ingredients that will help support you on your journey to better health.

It’s the Nuturna Maximum Strength Neuropathy Support  Formula with 600mg of ALA.